Which of the following is a risk factor for ICU-acquired weakness?

• A. Multi-organ failure
• B. Single organ failure
• C. Young age
• D. Low-dose antibiotics

Answer: (A)

Multi-organ failure reflects a high severity of illness with widespread systemic effects that drive ICU-acquired weakness. When several organs fail, the body experiences pervasive inflammation, metabolic disturbances, and prolonged immobilization, all of which accelerate muscle protein breakdown, impair nerve function, and reduce mitochondrial efficiency. This combination creates a deep, persistent weakness that develops during the ICU stay. In contrast, failure of a single organ indicates less systemic disruption, young age is generally not a risk factor for ICU-AW, and low-dose antibiotics do not contribute to the processes that cause ICU-acquired weakness.